National Board of Osteopathic Medical Examiners (NBOME) · COMLEX-USA Blueprint, revised February 2025, specifications applicable on 2026-10-09. NBOME identifies this version for Level 2-CE testing on or before April 22, 2028; Blueprint 2.0 specifications begin in June 2028. The workbook label 'Comprehensive Osteopathic Medical Licensing Examination Level 2' maps to the current COMLEX-USA Level 2-Cognitive Evaluation examination. The assigned slug is preserved.

This original 20-question sample covers selected topics across the outline. It does not reproduce official exam questions or cover every tested topic.

• COMLEX-USA — NBOME
• COMLEX-USA Level 2-CE — NBOME
• COMLEX-USA Blueprint — NBOME
• NBOME Introduces COMLEX-USA Blueprint 2.0
• Description of COMLEX-USA Examinations — Bulletin of Information
• Retired Assessments — NBOME
• AACOM Authorized Osteopathic Thesaurus, A–E, published 2004
• AACOM Authorized Osteopathic Thesaurus, E–J, published 2004
• Tenets of Osteopathic Medicine — American Osteopathic Association
• Syphilis During Pregnancy — CDC STI Treatment Guidelines
• 2021 AHA/ACC Chest Pain Guideline Slide Set
• Preventing and Managing Adverse Reactions — CDC
• Low Blood Glucose (Hypoglycemia) — NIDDK
• Symptoms & Causes of Kidney Infection (Pyelonephritis) — NIDDK
• Diagnosis of GI Bleeding — NIDDK
• Stroke Diagnosis — NHLBI
• Thyroid Tests — NIDDK
• Iron-Deficiency Anemia — NHLBI
• COPD Diagnosis — NHLBI
• IDSA Guidelines for Skin and Soft Tissue Infections, 2014
• Gout — American College of Rheumatology
• Cochrane Handbook, Chapter 15: Interpreting Results and Drawing Conclusions
• What Are Diagnostic Test Accuracy Reviews? — Cochrane
• Use the Teach-Back Method: Tool 5 — AHRQ
• Patient Rights — AMA Code of Medical Ethics
• Promoting Patient Safety — AMA Code of Medical Ethics
• Decisions for Adult Patients Who Lack Capacity — AMA Code of Medical Ethics
• Medication Reconciliation — AHRQ PSNet
• Treatment of Low Blood Sugar (Hypoglycemia) — CDC
• Total Iron Binding Capacity — MedlinePlus Medical Encyclopedia
• Advance Directives — AMA Code of Medical Ethics
• thesaurus-2004-j-p.pdf
• GOLD-REPORT-2026-v1.2-20Nov2025_WMV.pdf
• Gout: Diagnosis, Treatment, and Steps to Take
• Recommendations | Gout: diagnosis and management | Guidance | NICE
• DailyMed - ALLOPURINOL tablet
• gout-guideline-2020.pdf
• JBJI - Guideline for management of septic arthritis in native joints (SANJO)
• DailyMed - EPIPEN- epinephrine injection
• Hyperthyroidism in Pregnancy | American Thyroid Association
• GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD - PMC
• Vascular Monosodium Urate Crystal Deposition in Gout: A Dual-energy CT and Microscopy Study of Cadaveric Donors - ACR Meeting Abstracts
• 3.2.1.pdf
• Joint statement from GOLD/GLI regarding the use of spirometry to define airflow obstruction and diagnose COPD - PMC
• Thyroiditis | American Thyroid Association
• file
• KDIGO-2012-AKI-Guideline-English.pdf
• KDIGO-2024-CKD-Guideline.pdf
• Identify & Evaluate Patients with Chronic Kidney Disease - NIDDK
• Adult Outpatient Brief Suicide Safety Assessment Guide - National Institute of Mental Health (NIMH)
• Depression - National Institute of Mental Health (NIMH)