American Society for Clinical Pathology Board of Certification (ASCP BOC) · ASCP BOC Chemistry Examination Content Guideline, revised December 5, 2025, current official outline identified as of October 15, 2026. No separate effective date is stated. The assigned workbook label maps directly to Specialist in Chemistry, SC(ASCP). The shared guideline also covers SC(ASCPi); specialist-specific content and weights are used here.

This original 20-question sample covers selected topics across the outline. It does not reproduce official exam questions or cover every tested topic.

• ASCP BOC: Chemistry Examination Suggested Reading
• ASCP BOC Chemistry Examination Content Guideline — revised December 5, 2025
• NGSP: Factors that Interfere with HbA1c Test Results
• Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
• Estimating low-density lipoprotein cholesterol by the Friedewald equation
• Mayo Clinic Laboratories: Bilirubin, Serum
• Ohio State Wexner Medical Center Laboratories: Bilirubin, Total and Direct
• Mayo Clinic Laboratories: Creatinine, Random, Urine
• Mayo Clinic: Gamma-glutamyl transferase blood test
• Mayo Clinic Laboratories: Ammonia, Plasma
• Michigan Medicine MLabs: Protein Electrophoresis, Serum
• American Thoracic Society: Interpretation of Arterial Blood Gases
• Impact of an air bubble within the syringe on test results obtained with a modern blood gas analyzer
• Preventing pseudohyponatremia: Intralipid-based lipemia cutoffs for sodium are inappropriate
• American Thyroid Association: Thyroid Function Tests
• Mayo Clinic Laboratories: Phenytoin, Total and Phenobarbital Group, Serum
• NIH Office of Dietary Supplements: Vitamin B12 — Health Professional Fact Sheet
• CMS: Verification of Performance Specifications
• NIST: Accuracy in Analytical Spectrophotometry
• Mayo Clinic Laboratories: Fructosamine, Serum
• Mayo Clinic: Blood tests for heart disease
• Radiometer: pH
• University of Iowa: Osmolality Gap — Calculation and Interpretation
• Mayo Clinic Laboratories: Iron and Total Iron-Binding Capacity, Serum
• Mayo Clinic Laboratories: Calcium, Ionized, Serum
• FDA: Drugs of Abuse Home Use Test
• FDA: Biotin Interference with Troponin Lab Tests
• NIST Dataplot: Coefficient of Variation
• CMS: Proficiency Testing and PT Referral
• FDA: Statistical Guidance on Reporting Results from Studies Evaluating Diagnostic Tests
• CMS: Assessing Personnel Competency
• CMS: Calibration and Calibration Verification
• NIDDK: The A1C Test and Diabetes
• CDC NIOSH: Methanol — Systemic Agent
• OSHA: Bloodborne Pathogens Standard
• Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus — publisher version
• Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin
• Mayo Clinic Laboratories: Porphobilinogen, Quantitative, Random, Urine
• NIH Office of Dietary Supplements: Vitamin D — Health Professional Fact Sheet