Practise diagnostic testing, urgent treatment, prevention, communication, and evidence interpretation through 60 selective concepts, 20 original questions, and 20 flashcards. These are independent learning materials, not official exam questions or a pass prediction.
Read the USMLE Step 2 CK: Clinical Decisions and Applied Knowledge study guide and official exam sourcesExam outline and official sources
Federation of State Medical Boards (FSMB) and NBME, joint sponsors of the USMLE program · USMLE Content Outline, public-release 2026 edition; current Step 2 CK content specifications reviewed on 2026-10-09. The specifications webpage does not state a blueprint effective date. Workbook 'United States Medical Licensing Examination Step 2' maps to the current Step 2 Clinical Knowledge (CK) examination; the assigned slug is preserved. Step 2 CS is discontinued. The 2026 Bulletin and its service-transition addendum apply to 2026 eligibility periods; the already-published 2027 Bulletin is prospective for 2027 eligibility periods.
This original 20-question sample covers selected topics across the outline. It does not reproduce official exam questions or cover every tested topic.
- Step 2 CK
- Step 2 CK Exam Content
- USMLE Content Outline — Public Release 2026
- USMLE Physician Tasks/Competencies
- 2026 Bulletin of Information
- 2026 Bulletin of Information Addendum
- Bulletin of Information
- 2027 Bulletin of Information
- Work to relaunch USMLE Step 2 CS discontinued
- AMA Code of Medical Ethics: Informed Consent
- Root Cause Analysis
- Guide to Improving Patient Safety: Teach-Back
- CDC STI Treatment Guidelines: Pelvic Inflammatory Disease
- Glomerular Disease
- AHA 2025 Adult Tachyarrhythmia With a Pulse Algorithm
- Heart Failure — Diagnosis
- Guideline for management of septic arthritis in native joints (SANJO)
- AAOS OrthoInfo: Compartment Syndrome
- Bipolar Disorder
- Vitamin B12 — Health Professional Fact Sheet
- Iron — Health Professional Fact Sheet
- Celiac Disease Tests
- Folic Acid Supplementation to Prevent Neural Tube Defects: Preventive Medication
- Stroke — Diagnosis
- 2026 GINA Summary Guide
- GINA 2026 Summary Guide for Asthma Management and Prevention
- CDC Pink Book, Chapter 16: Pertussis
- World Allergy Organization Anaphylaxis Guidance 2020
- Diabetic Ketoacidosis
- CDC Field Epidemiology Manual: Analyzing and Interpreting Data
- Hyperglycaemic crises in adults with diabetes: a consensus report
- 2.1.1.pdf
- Psychiatry.org - What Are Bipolar Disorders?
- WAO-ANAPHYLAXIS-GUIDE-2020.pdf
- Client Challenge
- Nephrotic Syndrome in Adults - NIDDK
- Psychiatry.org - Bipolar Disorders
- Symptoms & Causes of Appendicitis - NIDDK
- Diagnosis of Appendicitis - NIDDK
- Ectopic Pregnancy | Tubal Pregnancy | MedlinePlus
- Developmental Surveillance and Screening Patient Care
United States Medical Licensing Examination (USMLE) Step 2 Clinical Knowledge (CK)
Start with 20 free questions, then review the explanations and any topics you missed.
A 46-year-old with prior gastric surgery reports progressive tingling in both feet. Hemoglobin is normal, serum vitamin B12 is borderline, and kidney function is normal. Which test would most directly clarify functional B12 deficiency?
United States Medical Licensing Examination (USMLE) Step 2 Clinical Knowledge (CK)
Flashcards
Nutrition
Vitamin B12 assessment
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